Also the drawbacks of the clinical studies involved in the article, unmet needs and prospective development for DILI therapy were discussed.

The current article reviewed the accumulated literature with evidence-based medicine researches for DILI in clinical practice. Reference to clinical patterns and disease severity grades of DILI, the treatment drugs were considered to summarize into hepatoprotective drugs (N-acetylcysteine and Glutathione, Glycyrrhizin acid preparation, Polyene phosphatidylcholine, Bicyclol, Silymarin), anticholestatic drug (Ursodeoxycholic acid, S-adenosylmethionine, Cholestyramine), immunosuppressants (Glucocorticoids) and specific treatment agents (L-carnitine, Anticoagulants). For the management of DILI, discontinuation of suspicious drug or medicine is the first step, but the treatments including drugs and supporting approaches are needed. 4Shanghai Innovation Center of TCM Health Service, Shanghai, Chinaĭrug-induced liver injury (DILI) has become a serious public health problem.3Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai, China.2Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China.1Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.Meng Li 1, Qiong Luo 1, Yanyan Tao 1, Xin Sun 1,2* and Chenghai Liu 1,2,3,4*

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